HBOT - Gas Gangrene - Clostridia Myositis or Myonecrosis:

Hyperbaric oxygen therapy has several specific biological actions which can enhance wound healing processes. Hyper-oxygenation of tissue, vasoconstriction, down regulation of inflammatory cytokines, up-regulation of growth factors, antibacterial effects, potentiation of antibiotics, and leukocyte effects.

Gas Gangrene is an acute, rapidly invasive infection of the muscle characterized by profound toxemia, extensive edema, massive death of tissue and variable degree of gas production. To put in simple terms, Gas gangrene is a serious infection secondary to the gas forming bacteria Clostridium. This bacteria contaminates the wound and allows gas to get trapped under the skin, killing body tissue.

Hyperbaric oxygen therapy is able to combat clinical infection such as gas gangrene by acting directly on anaerobic bacteria, enhancing leukocyte and macrophage activity and potentiating the effects of antibiotics.

The goal of HBO therapy is to stop alpha-toxin production, requiring tissue oxygen concentrations of 250 mm Hg, to inhibit further bacterial growth. Also aims to keep swelling down and bacteria from spreading to other parts of the body. The greatest reduction in mortality results from treatment utilizing HBOT, antibiotic therapy and surgery.

Hyperbaric oxygen Therapy is a tissue, limb and life-saving treatment of myonecrosis.
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